Traditionally, it has been assumed that immunological memory is exclusively located in our adaptive immune system. Pioneering work from Trained Therapeutix Discovery founders Mihai Netea and Leo Joosten has revealed that the innate immune systems also has adaptive characteristics. This de facto innate immune memory is called ‘trained immunity’.
What we do
At Trained Therapeutix Discovery we employ advanced bioengineering methods to produce nanobiologic therapeutics. Nanobiologics are therapeutic materials constructed from molecular building blocks that our body produces naturally.
The advantage of this approach is that we ‘hijack’ natural mechanisms to engage the immune system with materials that are inherently well tolerated by the body, allowing us to take control of the immune response by regulating trained immunity. The Trained Therapeutix Discovery nanobiologic platform technology is fully modular, flexible, and can be judiciously finetuned.
Nanobiologic therapeutics are intravenously administered to engage hematopoietic organs, namely the bone marrow and spleen, and regulate trained immunity to control immune cell production bias.
Using this approach, we can dampen the ruinous hyperinflammation that occurs after organ transplantation or caused by coronavirus disease COVID-19. Similarly, using a reverse approach, we can induce an immune response against tumors.
